{"id":226,"date":"2023-08-24T14:34:40","date_gmt":"2023-08-24T14:34:40","guid":{"rendered":"https:\/\/geographicatrophy.uk\/?page_id=226"},"modified":"2024-03-14T10:27:23","modified_gmt":"2024-03-14T10:27:23","slug":"geographic-atrophy-progression","status":"publish","type":"page","link":"https:\/\/geographicatrophy.uk\/geographic-atrophy-progression\/","title":{"rendered":"GA progression"},"content":{"rendered":"
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Geographic atrophy
progression<\/h1>\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\t\t\t\t\"Geographic\n\t\t\t
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Geographic atrophy progression is continuous and irreversible.1\u20134<\/sup><\/h2>\n<\/div>\n\n
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While lesion growth in geographic atrophy may appear to proceed slowly, disease progression is continuous and irreversible.<\/strong><\/p>\n<\/div><\/div>\n\n\n\n

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Geographic atrophy progression is continuous and irreversible.1\u20134<\/sup><\/h2>\n<\/div>\n\n
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While lesion growth in geographic atrophy may appear to proceed slowly, disease progression is continuous and irreversible.<\/strong><\/p>\n<\/div>\n\n

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Growth of GA lesions lead to visual impairment<\/strong>, even before lesion growth reaches the fovea.<\/p>\n<\/div><\/div>\n\n\n\n

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\"Geographic<\/figure>\n<\/div><\/div>\n\n\n\n
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Geographic atrophy progression is continuous and irreversible.1\u20134<\/sup><\/h2>\n<\/div>\n\n
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Growth of GA lesions lead to visual impairment<\/strong>, even before lesion growth reaches the fovea.<\/p>\n<\/div>\n\n

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Of the 397 patients<\/strong> who developed central GA, the median time to foveal encroachment was only 2.5 years from diagnosis<\/strong>, according to a prospective AREDS study (N=3640).<\/p>\n<\/div><\/div>\n\n\n\n

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\"Geographic<\/figure>\n<\/div><\/div>\n\n\n\n
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Geographic atrophy progression is continuous and irreversible.1\u20134<\/sup><\/h2>\n<\/div>\n\n
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Of the 397 patients<\/strong> who developed central GA, the median time to foveal encroachment was only 2.5 years from diagnosis<\/strong>, according to a prospective AREDS study (N=3640).<\/p>\n<\/div>\n\n

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\"5<\/figure>\n<\/div>\n\n
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Currently geographic atrophy affects more than 5 million people worldwide.1<\/sup><\/p>\n<\/div><\/div>\n\n\n\n

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From age 50, prevalence quadruples every 10 years.<\/strong>5<\/strong><\/sup><\/p>\n<\/div><\/div>\n\n\n\n

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Geographic atrophy accounts for around 25% of all legal blindness <\/strong>attributed to AMD.6\u20138<\/sup><\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n

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\"vice<\/figure>\n<\/div>\n\n
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An eye with geographic atrophy can also naturally develop wet AMD.9<\/sup><\/p>\n<\/div><\/div>\n\n\n\n

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\"98%\n\"\/<\/figure>\n<\/div>\n\n
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of patients with wet AMD progressed to geographic atrophy<\/strong> over an average of 7.3 years of follow-up.10<\/sup><\/p>\n<\/div><\/div>\n\n\n\n

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Geographic atrophy is characterised by progressive and irreversible loss of the photoreceptors, retinal pigment epithelium (RPE) and underlying choriocapillaris.1,11<\/sup><\/h2>\n<\/div>\n\n
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Regions of atrophy typically start outside the fovea and expand to involve the fovea, which \u2013 over time \u2013 leads to permanent loss of vision.11<\/sup><\/p>\n<\/div>\n\n

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\"Fundus<\/figure><\/div>\n\n
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Fundus photograph of a healthy eye<\/strong><\/p>\n<\/div>\n\n\n\n

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Fundus photograph of an eye with geographic atrophy<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n\n

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Causes of geographic atrophy<\/h2>\n<\/div>\n\n
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Age-related macular degeneration is a complex, multifactorial disease and geographic atrophy pathogenesis encompasses a complex interaction of genetic, physiological and environmental factors.12\u201315<\/sup><\/p>\n<\/div>\n\n

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\"genetics\"<\/figure>\n<\/div>\n\n
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Genetics<\/strong><\/p>\n<\/div>\n\n

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